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Genomic reconstruction of an azole-resistant Candida parapsilosis outbreak and the creation of a multilocus sequence typing scheme: a retrospective observational and genomic epidemiology study
Background.
Fluconazole-resistant
Candida parapsilosis
has emerged as a significant healthcare-associated pathogen with a propensity to …
Phillip JT Brassington
,
Frank-Rainer Klefisch
,
Barbara Graf
,
Roland Pfüller
,
Oliver Kurzai
,
Grit Walther
,
Amelia E Barber
PDF
DOI
Unraveling the genomic diversity and virulence of human fungal pathogens through pangenomics
Marion Perrier
,
Amelia E Barber
PDF
DOI
A global survey of host, aquatic, and soil microbiomes reveals shared abundance and genomic features between bacterial and fungal generalists
Environmental change is reshaping microbial communities critical to Earth and human health. Loos, Pereira, et al. analyze 1,580 …
Daniel Loos
,
Ailton Pereira da Costa Filho
,
Bas E Dutilh
,
Amelia E Barber
,
Gianni Panagiotou
PDF
DOI
Breaking the mould: rethinking ‘wild type’ in fungal pathogens
In this Journal Club, Amelia Barber discusses a study revealing intraspecies heterogenity in a pathogen, prompting us to re-evaluate …
Amelia E Barber
PDF
DOI
Genome-scale metabolic modeling of Aspergillus fumigatus strains reveals growth dependencies on the lung microbiome
Aspergillus fumigatus
, an opportunistic human pathogen, frequently infects the lungs of people with cystic fibrosis and is one of the …
Mohammad H Mirhakkak
,
Xiuqiang Chen
,
Yueqiong Ni
,
Thorsten Heinekamp
,
Tongta Sae-Ong
,
Lin-Lin Xu
,
Oliver Kurzai
,
Amelia E Barber
,
Axel A Brakhage
,
Sebastien Boutin
,
Sascha Schaeuble
,
Gianni Panagiotou
PDF
DOI
Disruption of the Aspergillus fumigatus RNA interference machinery alters the conidial transcriptome
The RNA interference (RNAi) pathway has evolved numerous functionalities in eukaryotes, with many on display in Kingdom Fungi. RNAi can …
Abdulrahman A Kelani
,
Alexander Bruch
,
Flora Rivieccio
,
Corissa Visser
,
Thomas Krüger
,
Danielle Weaver
,
Xiaoqing Pan
,
Sascha Schaeuble
,
Gianni Panagiotou
,
Olaf Kniemeyer
,
Michael J Bromley
,
Paul Bowyer
,
Amelia E Barber
,
Axel A Brakhage
,
Matthew G Blango
PDF
DOI
A tRNA modifying enzyme as a tunable regulatory nexus for bacterial stress responses and virulence
Post-transcriptional modifications can impact the stability and functionality of many different classes of RNA molecules and are an …
Brittany A Fleming
,
Matthew G Blango
,
Alexis A Rousek
,
William M Kincannon
,
Alexander Tran
,
Adam J Lewis
,
Colin W. Russell
,
Qin Zhou
,
Lisa M Baird
,
Amelia E Barber
,
John R Brannon
,
Connor J Beebout
,
Vahe Bandarian
,
Maria Hadjifrangiskou
,
Michael T Howard
,
Matthew A Mulvey
PDF
DOI
Aspergillus fumigatus pan-genome analysis identifies genetic variants associated with human infection
Aspergillus fumigatus
is an environmental saprobe and opportunistic human fungal pathogen. Despite an estimated annual occurrence of …
Amelia E Barber
,
Tongta Sae-Ong
,
Kang Kang
,
Bastian Seelbinder
,
Jun Li
,
Grit Walther
,
Gianni Panagiotou
,
Oliver Kurzai
PDF
DOI
Effects of agricultural fungicide use on Aspergillus fumigatus abundance, antifungal susceptibility, and population structure
Antibiotic resistance is an increasing threat to human health. In the case of
Aspergillus fumigatus
, which is both an environmental …
Amelia E Barber
,
Jennifer Riedel
,
Tongta Sae-Ong
,
Kang Kang
,
Werner Brabetz
,
Holger B Deising
,
Oliver Kurzai
PDF
DOI
Low rate of azole resistance in cases of avian aspergillosis in Germany
Aspergillosis is the most common fungal disease of the avian respiratory tract. Due to delayed diagnosis and treatment failure, the …
Amelia E Barber
,
Sandra Scheufen
,
Grit Walther
,
Oliver Kurzai
,
Volker Schmidt
PDF
DOI
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