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The proteomic response of Aspergillus fumigatus to amphotericin B (AmB) reveals the involvement of the RTA-like protein RtaA in AmB resistance
The polyene antimycotic amphotericin B (AmB) and its liposomal formulation AmBisome belong to the treatment options of invasive …
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Genomic reconstruction of an azole-resistant Candida parapsilosis outbreak and the creation of a multilocus sequence typing scheme: a retrospective observational and genomic epidemiology study
Background. Fluconazole-resistant Candida parapsilosis has emerged as a significant health-care-associated pathogen with a propensity …
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Optimized psilocybin production in tryptophan catabolism-repressed fungi
The high therapeutic potential of psilocybin, a prodrug of the psychotropic psilocin, holds great promise for the treatment of mental …
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Optimized psilocybin production in tryptophan catabolism-repressed fungi
RNA: DNA triplexes: a mechanism for epigenetic communication between hosts and microbes?
Molecular communication between host and microbe is mediated by the transfer of many different classes of macromolecules. Recently, the …
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RNA: DNA triplexes: a mechanism for epigenetic communication between hosts and microbes?
Unraveling the genomic diversity and virulence of human fungal pathogens through pangenomics
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Unraveling the genomic diversity and virulence of human fungal pathogens through pangenomics
A global survey of host, aquatic, and soil microbiomes reveals shared abundance and genomic features between bacterial and fungal generalists
Environmental change is reshaping microbial communities critical to Earth and human health. Loos, Pereira, et al. analyze 1,580 …
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Breaking the mould: rethinking ‘wild type’ in fungal pathogens
In this Journal Club, Amelia Barber discusses a study revealing intraspecies heterogenity in a pathogen, prompting us to re-evaluate …
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Genome-scale metabolic modeling of Aspergillus fumigatus strains reveals growth dependencies on the lung microbiome
Aspergillus fumigatus, an opportunistic human pathogen, frequently infects the lungs of people with cystic fibrosis and is one of the …
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Disruption of the Aspergillus fumigatus RNA interference machinery alters the conidial transcriptome
The RNA interference (RNAi) pathway has evolved numerous functionalities in eukaryotes, with many on display in Kingdom Fungi. RNAi can …
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A tRNA modifying enzyme as a tunable regulatory nexus for bacterial stress responses and virulence
Post-transcriptional modifications can impact the stability and functionality of many different classes of RNA molecules and are an …
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