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Large-scale multi-omics profiling reveals environmental and evolutionary drivers of fungal phylogeographic and metabolic diversity
Small pangenome of Candida parapsilosis reflects overall low intraspecific diversity
Candida parapsilosis is an opportunistic yeast pathogen that can cause life-threatening infections in immunocompromised humans. Whole …
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Population structure in a fungal human pathogen is potentially linked to pathogenicity
Aspergillus flavus is a clinically and agriculturally important saprotrophic fungus responsible for severe human infections and …
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Aspergillus dsRNA virus drives fungal fitness and pathogenicity in the mammalian host
Aspergillus fumigatus accounts for approximately 65% of all invasive fungal infections in humans, with mortality rates from …
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mSphere of Influence: Population-level thinking to unravel microbial pathogenicity
Amelia E. Barber works in the field of fungal genomics and pathogenesis. In this mSphere of Influence article, she reflects on how the …
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The proteomic response of Aspergillus fumigatus to amphotericin B (AmB) reveals the involvement of the RTA-like protein RtaA in AmB resistance
The polyene antimycotic amphotericin B (AmB) and its liposomal formulation AmBisome belong to the treatment options of invasive …
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Genomic reconstruction of an azole-resistant Candida parapsilosis outbreak and the creation of a multilocus sequence typing scheme: a retrospective observational and genomic epidemiology study
Background. Fluconazole-resistant Candida parapsilosis has emerged as a significant health-care-associated pathogen with a propensity …
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Optimized psilocybin production in tryptophan catabolism-repressed fungi
The high therapeutic potential of psilocybin, a prodrug of the psychotropic psilocin, holds great promise for the treatment of mental …
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Optimized psilocybin production in tryptophan catabolism-repressed fungi
RNA: DNA triplexes: a mechanism for epigenetic communication between hosts and microbes?
Molecular communication between host and microbe is mediated by the transfer of many different classes of macromolecules. Recently, the …
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RNA: DNA triplexes: a mechanism for epigenetic communication between hosts and microbes?
Unraveling the genomic diversity and virulence of human fungal pathogens through pangenomics
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Unraveling the genomic diversity and virulence of human fungal pathogens through pangenomics